Statistical DNA Forensics

Inhaltsverzeichnis

Preface.
List of figures.

List of tables.

1. Introduction.

1.1 Statistics, forensic science and the law.

1.2 The use of statistics in forensic DNA.

1.3 Genetic basis of DNA profiling and typing technology.

1.3.1 Genetic basis.

1.3.2 Typing technology.

1.4 About the book.

2. Probability and statistics.

2.1 Probability.

2.2 Dependent events and conditional probability.

2.3 Law of total probability.

2.4 Bayes' Theorem.

2.5 Binomial probability distribution.

2.6 Multinomial distribution.

2.7 Poisson distribution.

2.8 Normal distribution.

2.9 Likelihood ratio.

2.10 Statistical inference.

2.10.1 Test of hypothesis.

2.10.2 Estimation and testing.

2.11 Problems.

3. Population genetics.

3.1 Hardy-Weinberg equilibrium.

3.2 Test for Hardy-Weinberg equilibrium.

3.2.1 Observed and expected heterozygosities.

3.2.2 Chi-square test.

3.2.3 Fisher's exact test.

3.2.4 Computer software.

3.3 Other statistics for analysis of a population database.

3.3.1 Linkage equilibrium.

3.3.2 Power of discrimination.

3.4 DNA profiling.

3.5 Subpopulation models.

3.6 Relatives.

3.7 Problems.

4. Parentage testing.

4.1 Standard trio.

4.1.1 Paternity index.

4.1.2 An example.

4.1.3 Posterior odds and probability of paternity.

4.2 Paternity computer software.

4.2.1 Steps in running the software.

4.2.2 The software to deal with an incest case.

4.3 A relative of the alleged father is the true father.

4.4 Alleged father unavailable but his relative is.

4.5 Motherless case.

4.5.1 Paternity index.

4.5.2 Computer software and example.

4.6 Motherless case: relatives involved.

4.6.1 A relative of the alleged father is the true father.

4.6.2 Alleged father unavailable but his relative is.

4.6.3 Computer software and example.

4.7 Determination of both parents.

4.8 Probability of excluding a random man from paternity.

4.9 Power of exclusion.

4.9.1 A random man case.

4.9.2 A relative case.

4.9.3 An elder brother case: mother available.

4.10 Other issues.

4.10.1 Reverse parentage.

4.10.2 Mutation.

4.11 Problems.

5. Testing for kinship.

5.1 Kinship testing of any two persons: HWE.

5.2 Computer software.

5.3 Kinship testing of two persons: subdivided populations.

5.3.1 Joint genotype probability.

5.3.2 Relatives involved.

5.4 Examples with software.

5.5 Three persons situation: HWE.

5.6 Computer software and example.

5.7 Three persons situation: subdivided populations.

5.7.1 Standard trio.

5.7.2 A relative of the alleged father is the true father.

5.7.3 Alleged father unavailable but his relative is.

5.7.4 Example.

5.7.5 General method and computer software.

5.8 Complex kinship determinations: method and software.

5.8.1 EasyPA-In-1-Minute software and the method.

5.8.2 EasyPAnt-In-1-Minute.

5.8.3 EasyIN-In-1-Minute.

5.8.4 EasyMISS-In-1-Minute.

5.8.5 Other considerations: probability of paternity and mutation.

5.9 Problems.

6. Interpreting mixtures.

6.1 An illustrative example.

6.2 Some common cases and a case example.

6.2.1 One victim, one suspect and one unknown.

6.2.2 One suspect and two unknowns.

6.2.3 Two suspects and two unknowns.

6.2.4 Case example.

6.2.5 Exclusion probability.

6.3 A general approach.

6.4 Population in Hardy-Weinberg equilibrium.

6.5 Population with multiple ethnic groups.

6.6 Subdivided population.

6.6.1 Single ethnic group: simple cases.

6.6.2 Single ethnic group: general situations.

6.6.3 Multiple ethnic groups.

6.7 Computer software and example.

6.8 NRC II Recommendation 4.1.

6.8.1 Single ethnic group.

6.8.2 Multiple ethnic groups.

6.9 Proofs.

6.9.1 The proof of Equation (6.6).

6.9.2 The proof of Equation (6.8).

6.9.3 The proof of Equation (6.9).

6.9.4 The proofs of Equations (6.11) and (6.12).

6.9.5 The proofs of Equations (6.14)

Statistical DNA Forensics

Theory, Methods and Computation

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eBook

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Beschreibung

Details

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.03.2008

Verlag

John Wiley & Sons Inc

Seitenzahl

264

Maße (L/B/H)

25/17,5/1,9 cm

Beschreibung

Details

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.03.2008

Verlag

John Wiley & Sons Inc

Seitenzahl

264

Maße (L/B/H)

25/17,5/1,9 cm

Gewicht

642 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-06636-2

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  • Statistical DNA Forensics
  • Preface.
    List of figures.

    List of tables.

    1. Introduction.

    1.1 Statistics, forensic science and the law.

    1.2 The use of statistics in forensic DNA.

    1.3 Genetic basis of DNA profiling and typing technology.

    1.3.1 Genetic basis.

    1.3.2 Typing technology.

    1.4 About the book.

    2. Probability and statistics.

    2.1 Probability.

    2.2 Dependent events and conditional probability.

    2.3 Law of total probability.

    2.4 Bayes' Theorem.

    2.5 Binomial probability distribution.

    2.6 Multinomial distribution.

    2.7 Poisson distribution.

    2.8 Normal distribution.

    2.9 Likelihood ratio.

    2.10 Statistical inference.

    2.10.1 Test of hypothesis.

    2.10.2 Estimation and testing.

    2.11 Problems.

    3. Population genetics.

    3.1 Hardy-Weinberg equilibrium.

    3.2 Test for Hardy-Weinberg equilibrium.

    3.2.1 Observed and expected heterozygosities.

    3.2.2 Chi-square test.

    3.2.3 Fisher's exact test.

    3.2.4 Computer software.

    3.3 Other statistics for analysis of a population database.

    3.3.1 Linkage equilibrium.

    3.3.2 Power of discrimination.

    3.4 DNA profiling.

    3.5 Subpopulation models.

    3.6 Relatives.

    3.7 Problems.

    4. Parentage testing.

    4.1 Standard trio.

    4.1.1 Paternity index.

    4.1.2 An example.

    4.1.3 Posterior odds and probability of paternity.

    4.2 Paternity computer software.

    4.2.1 Steps in running the software.

    4.2.2 The software to deal with an incest case.

    4.3 A relative of the alleged father is the true father.

    4.4 Alleged father unavailable but his relative is.

    4.5 Motherless case.

    4.5.1 Paternity index.

    4.5.2 Computer software and example.

    4.6 Motherless case: relatives involved.

    4.6.1 A relative of the alleged father is the true father.

    4.6.2 Alleged father unavailable but his relative is.

    4.6.3 Computer software and example.

    4.7 Determination of both parents.

    4.8 Probability of excluding a random man from paternity.

    4.9 Power of exclusion.

    4.9.1 A random man case.

    4.9.2 A relative case.

    4.9.3 An elder brother case: mother available.

    4.10 Other issues.

    4.10.1 Reverse parentage.

    4.10.2 Mutation.

    4.11 Problems.

    5. Testing for kinship.

    5.1 Kinship testing of any two persons: HWE.

    5.2 Computer software.

    5.3 Kinship testing of two persons: subdivided populations.

    5.3.1 Joint genotype probability.

    5.3.2 Relatives involved.

    5.4 Examples with software.

    5.5 Three persons situation: HWE.

    5.6 Computer software and example.

    5.7 Three persons situation: subdivided populations.

    5.7.1 Standard trio.

    5.7.2 A relative of the alleged father is the true father.

    5.7.3 Alleged father unavailable but his relative is.

    5.7.4 Example.

    5.7.5 General method and computer software.

    5.8 Complex kinship determinations: method and software.

    5.8.1 EasyPA-In-1-Minute software and the method.

    5.8.2 EasyPAnt-In-1-Minute.

    5.8.3 EasyIN-In-1-Minute.

    5.8.4 EasyMISS-In-1-Minute.

    5.8.5 Other considerations: probability of paternity and mutation.

    5.9 Problems.

    6. Interpreting mixtures.

    6.1 An illustrative example.

    6.2 Some common cases and a case example.

    6.2.1 One victim, one suspect and one unknown.

    6.2.2 One suspect and two unknowns.

    6.2.3 Two suspects and two unknowns.

    6.2.4 Case example.

    6.2.5 Exclusion probability.

    6.3 A general approach.

    6.4 Population in Hardy-Weinberg equilibrium.

    6.5 Population with multiple ethnic groups.

    6.6 Subdivided population.

    6.6.1 Single ethnic group: simple cases.

    6.6.2 Single ethnic group: general situations.

    6.6.3 Multiple ethnic groups.

    6.7 Computer software and example.

    6.8 NRC II Recommendation 4.1.

    6.8.1 Single ethnic group.

    6.8.2 Multiple ethnic groups.

    6.9 Proofs.

    6.9.1 The proof of Equation (6.6).

    6.9.2 The proof of Equation (6.8).

    6.9.3 The proof of Equation (6.9).

    6.9.4 The proofs of Equations (6.11) and (6.12).

    6.9.5 The proofs of Equations (6.14)