Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
01.06.2009
Verlag
VDMSeitenzahl
208
Maße (L/B/H)
22/15/1,2 cm
Gewicht
326 g
Sprache
Englisch
ISBN
978-3-639-16347-6
Myosins comprise a class of molecular motors that
move along actin filaments and deliver cargo to
specific cellular compartments. This book provides a
detailed examination of the mouse myosin XVa
biological function, characterization of full-length
mouse inner ear myosins VIIa, VIIb, X and XVa cDNA
transcripts and the cellular targeting of myosins
VIIa, VIIb, X and XVa in mouse inner ear hair cells.
Stereocilia are actin-filled projections on the
apical surface of inner ear hair cells that detect
mechanical stimuli of sound and head movement. The
precise arrangement of stereocilia rows in a
staircase-like pattern required for normal function
is disrupted by the failure of myosin XVa to deliver
whirlin to stereocilia tips resulting in deafness and
vestibular defects. In transfected mouse hair cells
deficient for myosin XVa function, the domains of
myosin XVa required for stereocilia tip targeting
were different than those required in the
re-initiation of stereocilia elongation and staircase
formation. The information in this book should be
especially useful to investigators in the fields of
neuroscience, biophysics, genetics and cell biology.
move along actin filaments and deliver cargo to
specific cellular compartments. This book provides a
detailed examination of the mouse myosin XVa
biological function, characterization of full-length
mouse inner ear myosins VIIa, VIIb, X and XVa cDNA
transcripts and the cellular targeting of myosins
VIIa, VIIb, X and XVa in mouse inner ear hair cells.
Stereocilia are actin-filled projections on the
apical surface of inner ear hair cells that detect
mechanical stimuli of sound and head movement. The
precise arrangement of stereocilia rows in a
staircase-like pattern required for normal function
is disrupted by the failure of myosin XVa to deliver
whirlin to stereocilia tips resulting in deafness and
vestibular defects. In transfected mouse hair cells
deficient for myosin XVa function, the domains of
myosin XVa required for stereocilia tip targeting
were different than those required in the
re-initiation of stereocilia elongation and staircase
formation. The information in this book should be
especially useful to investigators in the fields of
neuroscience, biophysics, genetics and cell biology.
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