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Produktbild: Neonatal Haematology

Neonatal Haematology A Practical Guide

161,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

06.09.2022

Verlag

John Wiley & Sons

Seitenzahl

304

Maße (L/B/H)

24,4/17/2 cm

Gewicht

738 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-37158-8

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

06.09.2022

Verlag

John Wiley & Sons

Seitenzahl

304

Maße (L/B/H)

24,4/17/2 cm

Gewicht

738 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-37158-8

Herstelleradresse

Produktsicherheitsverantwortliche/r
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Neonatal Haematology

  • Preface viii

    Abbreviations x

    1 The full blood count and blood film in healthy term and preterm neonates 1

    Introduction 1

    Brief outline of the ontogeny of haemopoiesis 1

    Properties of fetal haemopoietic stem and progenitor cells 2

    Red blood cell production and development in the fetus and neonate 5

    Erythropoietin production in the fetus and neonate 6

    Haemoglobin synthesis and red blood cell production in the fetus and newborn 6

    Red blood cell lifespan and the red blood cell membrane in the fetus and neonate 9

    Red blood cell metabolism in the fetus and neonate 10

    Iron metabolism in the fetus and neonate 11

    Normal values for red blood cell parameters in the fetus and neonate 12

    Leucocytes in the fetus and newborn 17

    Leucocyte production and function in the fetus and neonate 18

    Platelets and megakaryocytes in the fetus and neonate 23

    Developmental megakaryopoiesis and thrombopoiesis 23

    Platelet numbers in the neonate and fetus - normal values 24

    Neonatal platelet function 25

    Practical problems in interpreting neonatal blood counts and films 25

    Sample quality/artefacts 25

    Site of sampling 26

    Gestational age and postnatal age 27

    Pregnancy-associated complications and mode of delivery 28

    References 28

    2 Red cell disorders: Anaemia, jaundice, polycythaemia and cyanosis 38

    Neonatal anaemia 38

    Definition and clinical significance of neonatal anaemia 38

    Neonatal anaemia due to reduced red cell production 39

    Neonatal anaemia due to increased red cell destruction 47

    Neonatal anaemia due to haemoglobinopathies and other microcytic anaemias 67

    Neonatal anaemia due to blood loss 76

    Anaemia of prematurity 81

    A simple diagnostic approach to neonatal anaemia 83

    Neonatal polycythaemia 85

    Haematological causes of cyanosis 86

    Principles of red cell transfusion in neonates 86

    Illustrative cases 88

    Abbreviations used in the illustrative cases 110

    References 110

    3 Neonatal infection and leucocyte disorders 128

    Leucocyte abnormalities in neonatal systemic disease 128

    Increases in leucocyte numbers 128

    Neonatal infection and its differential diagnosis: clues from the blood count and blood film 135

    Storage disorders: diagnostic clues from the blood film 144

    Neonatal neutropenia 145

    Definition and causes of neutropenia 145

    Immune neutropenia 148

    Inherited congenital or neonatal neutropenia 150

    Haematological features of neonates with Down syndrome 154

    Congenital leukaemia 154

    Leukaemia and preleukaemia in neonates with Down syndrome 156

    Acute leukaemia in neonates without Down syndrome 160

    Juvenile myelomonocytic leukaemia and Noonan syndrome myeloproliferative disorder 168

    Illustrative cases 169

    Abbreviations used in the illustrative cases 176

    References 176

    4 Disorders of platelets and coagulation, thrombosis and blood transfusion 190

    Thrombocytopenia overview 190

    Causes of neonatal thrombocytopenia: a practical classification based on age at onset 192

    Fetal thrombocytopenia 194

    Early-onset neonatal thrombocytopenia (presenting at <72 hours of age) 194

    >72 hours of age) 196

    Conditions leading to clinically significant thrombocytopenia in the neonate 197

    Fetal/neonatal alloimmune thrombocytopenia 197

    Neonatal thrombocytopenia due to maternal autoimmune disease 200

    Thrombocytopenia due to congenital infections 201

    Neonatal thrombocytopenia associated with chromosomal abnormalities 205

    Inherited thrombocytopenia 206

    Investigation of neonatal thrombocytopenia 215

    Management of neonatal thrombocytopenia 215

    Indications for platelet transfusion 216

    Platelet function disorders 217

    Inherited platelet function disorders with normal platelet counts presenting in the neonate 218

    Thrombocytosis 218

    Abnormalities of coagulation 220

    Developmental haemostasis 220

    Laboratory investigation of coagulation disorders in the neonate 220

    Acquired coagulation abnormalities 221

    Inherited coagulation disorders 223

    Thrombosis 224

    Screening tests for thrombophilia in neonates 224

    Acquired thrombotic abnormalities 225

    Inherited thrombotic abnormalities 225

    General principles of neonatal platelet and plasma component transfusion 226

    Platelet transfusion 226

    Fresh frozen plasma 226

    Cryoprecipitate 227

    Prothrombin complex and recombinant factor VIIa 227

    Illustrative cases 227

    Abbreviations used in the illustrative cases 233

    References 234

    Index 254