Contributors xi
Series Preface xvii
Preface xix
Acknowledgments xxi
Part A: Concepts, Theory, & Instrumentation 1
1 The Discovery and Demonstration of Dynamic Nuclear Polarization-A Personal and Historical Account 3
Charles P. Slichter
2 DNP Mechanisms 15
Krishnendu Kundu, Frédéric Mentink-Vigier, Akiva Feintuch, and Shimon Vega
3 Pulsed Dynamic Nuclear Polarization 71
Kong Ooi Tan, Sudheer Jawla, Richard J. Temkin, and Robert G. Griffin
4 MAS-DNP Enhancements: Hyperpolarization, Depolarization, and Absolute Sensitivity 87
Sabine Hediger, Daniel Lee, Frédéric Mentink-Vigier, and Gaël De Paëpe
5 Polarizing Agents: Evolution and Outlook in Free Radical Development for DNP 103
Gilles Casano, Hakim Karoui, and Olivier Ouari
6 Paramagnetic Metal Ions for Dynamic Nuclear Polarization 121
Björn Corzilius
7 Instrumentation for High-field Dynamic Nuclear Polarization NMR Spectroscopy 143
Guy M. Bernard and Vladimir K. Michaelis
8 Millimeter-wave Sources for DNP-NMR 155
Monica Blank and Kevin L. Felch
9 Cryogenic Platforms and Optimized DNP Sensitivity 169
Yoh Matsuki and Toshimichi Fujiwara
10 Versatile Dynamic Nuclear Polarization Hardware with Integrated Electron Paramagnetic Resonance Capabilities 189
Alisa Leavesley, Ilia Kaminker, and Songi Han
11 Dissolution Dynamic Nuclear Polarization Methodology and Instrumentation 219
Dennis Kurzbach and Sami Jannin
12 Introduction to Dissolution DNP: Overview, Instrumentation, and Human Applications 239
Jan H. Ardenkjaer-Larsen
13 Liquid-state Overhauser DNP at High Magnetic Fields 261
Vasyl P. Denysenkov and Thomas F. Prisner
14 Overhauser DNP in Liquids on 13C Nuclei 279
Marina Bennati and Tomas Orlando
Part B: Applications 289
15 DNP and Cellular Solid-state NMR 291
Alessandra Lucini Paioni, Marie A.M. Renault, and Marc Baldus
16 Cryo-trapped Intermediates of Retinal Proteins Studied by DNP-enhanced MAS NMR Spectroscopy 305
Johanna Becker-Baldus and Clemens Glaubitz
17 DNP Solid-state NMR of Biological Membranes 323
Burkhard Bechinger
18 DNP in Materials Science: Touching the Surface 337
Pierrick Berruyer, Lyndon Emsley, and Anne Lesage
19 Growing Signals from the Noise: Challenging Nuclei in Materials DNP 353
Frédéric A. Perras, Takeshi Kobayashi, and Marek Pruski
20 DNP-enhanced Solid-state NMR Spectroscopy of Active Pharmaceutical Ingredients 373
Li Zhao, Arthur C. Pinon, Lyndon Emsley, and Aaron J. Rossini
21 In Vivo Hyperpolarized 13C MRS and MRI Applications 405
Irene Marco-Rius and Arnaud Comment
22 Dissolution Dynamic Nuclear Polarization 421
Walter Köckenberger
Index 435
