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Produktbild: Endocrine Disrupters

Endocrine Disrupters

171,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

25.03.2013

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

24/16,1/2,7 cm

Gewicht

783 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-93209-4

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

25.03.2013

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

24/16,1/2,7 cm

Gewicht

783 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-93209-4

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Endocrine Disrupters
  • Preface ix
     
    Contributors xi
     
    1 Ecotoxicity Test Methods for Endocrine-Disrupting Chemicals: An Introduction 1
    Peter Matthiessen
     
    1.1 Background 1
     
    1.2 Regulatory Concerns 2
     
    1.3 Invertebrates 2
     
    1.4 Vertebrates 3
     
    1.5 Testing Schemes for EDCs 5
     
    Reference 6
     
    2 Endocrine Disruption inWildlife: Background, Effects, and Implications 7
    Dick Vethaak and Juliette Legler
     
    2.1 Background to Endocrine Disruption 8
     
    2.2 Effects of EDCs on Wildlife 19
     
    2.3 Weight of Evidence and Ecological Significance of ED Effects 32
     
    2.4 Implications for Effect Assessment and Toxicity Testing 36
     
    2.5 Need for More Field Studies and an Integrated Approach 38
     
    2.6 Concluding Points 39
     
    References 40
     
    3 The Regulatory Need for Tests to Detect EDCs and Assess Their Hazards toWildlife 59
    Hans-Christian Stolzenberg, Tobias Frische, Vicki L. Dellarco, Gary Timm, Anne Gourmelon, Taisen Iguchi, Flemming Ingerslev, and Mike Roberts
     
    3.1 Emerging Concerns and Policy Responses: Focusing on EDCs as a Large Pseudo-Uniform Group of Substances 60
     
    3.2 General Approaches in Substance-Related Regulatory Frameworks (EU) 80
     
    3.3 How to Make EDC Definitions Operational for Substance-Related Regulatory Work 87
     
    3.4 Future Perspectives 91
     
    3.5 Conclusions 92
     
    References 93
     
    4 Techniques for Measuring Endocrine Disruption in Insects 100
    Lennart Weltje
     
    4.1 Introduction 100
     
    4.2 Methods 105
     
    4.3 Discussion 108
     
    4.4 Conclusion 110
     
    4.5 Acknowledgments 110
     
    References 110
     
    5 Crustaceans 116
    Magnus Breitholtz
     
    5.1 Introduction 116
     
    5.2 Background to Crustacean Endocrinology 118
     
    5.3 State of the Art: What Do We Know About Endocrine Disruption in Crustaceans? 121
     
    5.4 Available Subchronic/Chronic Standard Test Protocols 128

    5.5 Complementary Tools for Identification of Endocrine Disruption 129
     
    5.6 Summary and Conclusions 132
     
    References 134
     
    6 Endocrine Disruption in Molluscs: Processes and Testing 143
    Patricia D. McClellan-Green
     
    6.1 Background and Introduction 143
     
    6.2 What Constitutes the Endocrine System in Molluscs? 145
     
    6.3 End Points and Biomarkers of Endocrine Disruption 154
     
    6.4 Current Test Methods Using Molluscs 164
     
    6.5 Proposed Test Methods 167
     
    6.6 Conclusions 171
     
    References 172
     
    7 Using Fish to Detect Endocrine Disrupters and Assess Their Potential Environmental Hazards 185
    Peter Matthiessen
     
    7.1 Introduction 185
     
    7.2 International Efforts to Standardize Fish-Based Methods for Screening and Testing Endocrine-Disrupting
     
    7.3 Fish-Based Screens Developed by OECD for Endocrine-Disrupting Chemicals 189
     
    7.4 Progress with Developing Fish Partial Life Cycle Tests for Endocrine Disrupters 194
     
    7.5 Prospects for the Standardization of Fish Full Life Cycle and Multigeneration Tests 195

    7.6 Strengths and Weaknesses of a Hazard Evaluation Strategy Based Partly on Available and Proposed Fish Screens and Tests 197
     
    7.7 Conclusions 198
     
    References 198
     
    8 Screening and Testing for Endocrine-Disrupting Chemicals in Amphibian Models 202
    Daniel B. Pickford
     
    8.1 Introduction 202
     
    8.2 Potential Uses of Amphibians in Endocrine Disrupter Screening and Testing Programs 203
     
    8.3 Embryonic Development 205
     
    8.4 Hatching 208
     
    8.5 Larval Development 209
     
    8.6 Higher-Tier Tests with Amphibians 224
     
    8.7 Other and Emerg