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Produktbild: Blood Substitutes

Blood Substitutes

291,99 €

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.2006

Verlag

Academic Press

Seitenzahl

576

Maße (L/B/H)

28,6/22,5/3,7 cm

Gewicht

1900 g

Sprache

Englisch

ISBN

978-0-12-759760-7

Beschreibung

Rezension

"Robert Winslow's new book Blood Substitutes, is useful in many ways. It brings together well-written summaries of the work of many of the most important investigators of the last 2 decades in the broad group of interrelated fields. Moreover, it also has some excellent chapters of scientific and medical background that provide context for the work. It also gives a historical snapshot of the thinking and attitudes of workers in the field. As an introduction to the field, this book is outstanding." --John R. Hess MD, MPH, FACPa, University of Maryland Medical Center for TRANSFUSION MEDICINE REVIEWS (2006)"There aren't too many all in one books on this subject, let alone one written this clearly, concisely, and with perspective. If you are interested in this field, get this book." --Doody's 3 Star Review by Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital (2006)"This is a serious, comprehensive, authoritative and highly readable textbook on a most relevant and challenging topic - the search for blood substitutes. ...The Editor and publishers have clearly given considerable thought to the readability as well as the academic rigour of the 46 chapters and 548 pages. In this reviewer's opinion, they have been most successful. The font and the page layouts are easy on the eye, the illustrations of good quality, and the references for each chapter are comprehensive and up to date. The potential readership for this book will undoubtedly be broadly based. This is a quality text book, and, although it is always difficult to define quality, we do recognise it when we come across it." --Professor Ken Taylor, British Heart Foundation Professor of Cardiac Surgery, University of London and Director of Cardiac Services, Hammersmith Hospital, London, UK

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.01.2006

Verlag

Academic Press

Seitenzahl

576

Maße (L/B/H)

28,6/22,5/3,7 cm

Gewicht

1900 g

Sprache

Englisch

ISBN

978-0-12-759760-7

EU-Ansprechpartner

Kolibri 360 GmbH
Ettore-Bugatti-Straße 6-14
51149 Köln
DE
produktsicherheit@kolibri360.de

Herstelleradresse

A&C Black Publishers Ltd.
36 Soho Square
W1D 3QY London
UK
enquiries@acblack.com

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  • Produktbild: Blood Substitutes
  • Section 1: Background

    Introduction

    Chapter 1: Historical Background

    Chapter 2: Transfusion Medicine

    Chapter 3: Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice

    Section 2: Physiological Basis

    Introduction

    Chapter 4: Clinical Physiology: Oxygen Transport and the Transfusion Trigger

    Chapter 5: The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-free Hemoglobins

    Chapter 6: Oxygen Transport Properties of Hemoglobin-Based Oxygen Carriers: Studies using Artificial Capillaries and Mathematical Simulation

    Chapter 7: Mechanisms of Oxygen Transport in the Microcirculation: Effects of Cell-Free Oxygen Carriers

    Chapter 8: Shear Stress Mechanotransduction and the Flow Properties of Blood

    Chapter 9: Local Regulation of Blood Flow

    Section 3: Clinical Applications

    Introduction

    Chapter 10: Clinical Indications for Blood Substitutes and Optimal Properties

    Chapter 11: Crystalloid Solutions

    Chapter 12: Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care

    Chapter 13: Surgical Hemorrhage

    Chapter 14: Clinical Trials in Cardiac Surgery

    Chapter 15: Hemodilution

    Chapter 16: Clinical Hemodilution

    Chapter 17: Potential for Blood Substitutes in Tissue Ischemia

    Section 4: Toxicity and Side Effects

    Introduction

    Chapter 18: Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies

    Chapter 19: Pro-Oxidant Activity of Hemoglobin and Endothelial Cytotoxicity

    Chapter 20: Renal Toxicity

    Chapter 21: Hemoglobin and Neurotoxicity

    Chapter 22: The Role of Inflammation in the Toxicity of Hemoglobin-Based Oxygen Carriers

    Chapter 23: Hemoglobin-Induced Myocardial Lesions

    Section 5: Perfluorocarbon-Based Oxygen Carriers

    Introduction

    Chapter 24: Fluorocarbon Emulsions as in vivo Oxygen Delivery Systems: Background and Chemistry

    Chapter 25: Fluosol®: The First Commercial Injectable Perfluorocarbon Oxygen Carrier

    Chapter 26: Perftoran®

    Chapter 27: Rational Development of Oxyfluor(TM)

    Chapter 28: Oxygent(TM), a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients

    Section 6: Hemoglobin-Based Oxygen Carriers

    Introduction

    Chapter 29: The Structural and Functional Properties of Hemoglobin and their Relevance for a Hemoglobin-Based Blood Substitute

    Chapter 30: Hemoglobin Modification

    Chapter 31: Designing Recombinant Hemoglobin for Use as a Blood Substitute

    Chapter 32: Design, Conformational, Functional and Physiological Characterization of Recombinant Polymeric Heme-Proteins

    Chapter 33: ¿¿-Crosslinked Hemoglobin

    Chapter 34: DCLHb and rHb1.1

    Chapter 35: Clinical Studies with DCLHb

    Chapter 36: Hemopure® (HBOC-201, Hemoglobin Glutamer-250 (Bovine)): Preclinical Studies

    Chapter 37: HBOC-201 (Hemoglobin Glutamer-250 (Bovine), Hemopure®): Clinical Studies

    Chapter 38: Polyhemoglobin-Enzymes as New-Generation Blood Substitutes and Oxygen Therapeutics

    Chapter 39: Surface Decoration of Hemoglobin with Polyethylene Glycol

    Chapter 40: Hemospan® (MP4), A Human Hemoglobin Modified with Maleimide-Polyethylene Glycol

    Chapter 41: Dextran-Hemoglobin

    Chapter 42: Development of Non-Extravasating Hemoglobin-Based Oxygen Carriers

    Section 7: Liposomes and Related Products

    Introduction

    Chapter 43: Liposome-Encapsulated Hemoglobin: History, Preparation and Evaluation

    Chapter 44: Hemoglobin Vesicles as a Molecular Assembly: Characteristics of Preparation Process and Performances as Artificial Oxygen Carriers

    Chapter 45: Nanodimension Biodegradable Polymeric Membrane Artificial Red Blood Cells

    Chapter 46: Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier