Hemato-Biochemical Alterations Induced by Bifenthrin in Goats Toxico-biochemical and oxidative stress induced by subacute toxicity of bifenthrin in goats

In this study on bifenthrin toxicity,seven healthy goats of either sex were divided into two groups. Animals of group A received only tap water, whereas group B animals received bifenthrin @ 5mg/Kg/b.w/day orally for 28 days. Various hemato-biochemical and oxidative stress parameters were studied on 0, 3, 7, 14, 21 and 28th day of intoxication. To study the reversal of alterations in these parameters a post exposure study on 7th and 14th day was conducted when no bifenthrin was administered to these animals. Bifenthrin decreased the levels of Hb, PCV and TEC against control values; however, it produced leucocytosis marked by lymphocytosis. Activities of erythrocyte and plasma cholinesterases were inhibited significantly whereas activity of plasma aminotransferases and phosphatases increased significantly. Among the oxidative stress parameters, significant increase in lipid peroxidation, decrease in the levels of glutathione and activities of SOD, CAT, GST and GPx were observed. However, alterations in all the parameters studied returned to the non-significant levels during the post treatment period.