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Produktbild: Jasper's Basic Mechanisms of the Epilepsies
Band 80

Jasper's Basic Mechanisms of the Epilepsies

Aus der Reihe Contemporary Neurology

306,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

07.05.2024

Abbildungen

204 illustrations

Herausgeber

Jeffrey L. Noebels + weitere

Verlag

Oxford University Press

Seitenzahl

1752

Maße (L/B/H)

27,4/18,8/7,4 cm

Gewicht

2790 g

Auflage

5th edition

Sprache

Englisch

ISBN

978-0-19-754946-9

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

07.05.2024

Abbildungen

204 illustrations

Herausgeber

Verlag

Oxford University Press

Seitenzahl

1752

Maße (L/B/H)

27,4/18,8/7,4 cm

Gewicht

2790 g

Auflage

5th edition

Sprache

Englisch

ISBN

978-0-19-754946-9

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Jasper's Basic Mechanisms of the Epilepsies


    • PREFACE


    • DEDICATION


    • ACKNOWLEDGMENTS


    • SECTION 1 - EVOLVING CONCEPTS


    • 1. The Paroxysmal Depolarizing Shift (PDS): The First Cellular Marker of Focal Epileptogenesis


    • David Prince and Massimo Avoli


    • 2. Hippocampal Sclerosis in Temporal Lobe Epilepsy: New Views and Challenges


    • Carolyn Houser


    • 3. Cerebral Cortical Dysplasia or Dysgenesis: Keratan Sulfate Proteoglycan for Fetal Axonal Guidance and Excitatory/Inhibitory Synaptic Targets that Influence Epileptogenesis


    • Harvey Sarnat and Laura Flores-Sarnat


    • 4. mTOR in Acquired and Genetic Models of Epilepsy


    • Michael Wong, Angelique Bordey, and Steve C. Danzer


    • 5. Epilepsy Genomics: Disease Causing Sequence Variants


    • Antonio Delgado-Escueta


    • SECTION 2 - SEIZURES, NETWORKS and SYSTEMS


    • Editor: Massimo Avoli; Associate Editors: Christophe Bernard and Marco de Curtis


    • Introduction


    • Massimo Avoli, Marco de Curtis, Christophe Bernard, and Ivan Soltesz


    • 6. GABAa-Receptor Signaling and Ionic Plasticity in the Generation and Spread of Seizures


    • Kai Kaila, Andrew Trevelyan, Joseph Raimondo, Tommi Ala-Kurikka, Gilles Huberfeld, Massimo Avoli, and Marco de Curtis


    • 7. Connexins, Pannexins and Epilepsy


    • Liang Zhang, Georg R. Zoidl, and Peter L. Carlen


    • 8. Mechanisms Leading to Initiation, Development and Termination of Focal Seizures


    • Marco de Curtis, Piotr Suffczynski, Maxime LÃ(c)vesque, Laura Librizzi,Laura Uva, Paolo Scalmani, Vadym Gnatkovsky, and Massimo Avoli


    • 9. Transition to Seizure from Cellular, Network, and Dynamical Perspectives


    • Wei-Chih Chang, Jan Kudlacek, Premysl Jiruska, and John G.R. Jefferys


    • 10. Role of the Subiculum in Focal Epilepsy


    • Alesya Evstratova, BelÃ(c)n Diaz-Fernandez, Maxime LÃ(c)vesque, Massimo Avoli, and Gand illes Huberfeld


    • 11. Optogenetic Modulation of Focal Seizures


    • Maxime LÃ(c)vesque, Massimo Avoli, and Merab Kokaia


    • 12. Balancing Seizure Control with Cognitive Side-Effects


    • Sheela Tropani, Gene G Gurkoff, Kiarash Shahlaie, Fady Girgis, Ignacio Saez, Jeffrey Kennedy, and Karen A Moxon


    • 13. High Frequency Oscillations


    • Liset Menendes de la Prida and Jean Gotman


    • 14. Seizures and Sleep


    • Birgit Frauscher and Igor Timofeev


    • 15. Cycles in epilepsy


    • Maxime Baud, Vikram Rao, Christophe Bernard, and Philippa Karoly


    • 16. Human Single Unit Recordings in Epilepsy


    • Edward Merricks and Catherine Schevon


    • 17. Role of Ion Concentration Dynamics in Epileptic Seizures


    • Oscar C González, Igor Timofeev, and Maxim Bazhenov


    • 18. A Classification of Seizures Based on Dynamics


    • Hiba Sheheitli, Huifang Wang, Jean-Didier Lemarechal, Christophe Bernard, and Viktor K. Jirsa


    • 19. Seizures, Networks and Systems - Computational EEG Analysis of Human Epileptogenic Networks


    • Vadim Gnatkovsky and Kaspar Schindler


    • 20. Excitation-Inhibition Balance in Absence Seizure Ictogenesis


    • Magor L. Lõrincz, Vincenzo Crunelli, and Francois David


    • 21. Cortical and Thalamic PV+ Interneuron Dysfunction in the Pathogenesis of Absence Epilepsy


    • Jochen Meyer and Atul Maheshwari


    • 22. Convergence of Thalamic Mechanisms in Genetic Epilepsies


    • Frances Cho and Jeanne Paz


    • Section 3 - EPILEPTOGENESIS: MOLECULAR MECHANISMS and TREATMENTS


    • Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and David Henshall


    • Introduction


    • Annamaria Vezzani and Helen Scharfman


    • 23. The Diverse Roles of Mossy Cells in the Normal Brain, Epileptogenesis, and Chronic Epilepsy


    • Helen Scharfman


    • 24. Temporal Lobe Epileptogenesis; A Focus on Etiology, Neuron Loss, The Latent Period, and Dentate Granule Cell Disinhibition


    • Robert Sloviter


    • 25. Adult Neurogenesis in Epileptogenesis and Comorbidities


    • Kyung-Ok Cho and Jenny Hsieh


    • 26. A Crucial Role for Astrocytes in Epileptogenesis: Gap Junctions and Glutamate Receptors


    • Peter Bedner, Allison R. Peterson, DevinK.Binder, Christian Steinhÿuser


    • 27. Adenosine Kinase: Cytoplasmic and Nuclear Isoforms


    • Madhuvika Murugan and Detlev Boison


    • 28. Inflammatory Astrocytic TGFß- Signaling Induced by Blood-Brain Barrier Dysfunction Drives Epileptogenesis


    • Lynn T. Yang, Giovanni Anthony, and Daniela Kaufer


    • 29. Pericytes and Microglia: Neurovascular and Immune Regulatory Cells in Seizure Disorders


    • Nicola Marchi and Amy Brewster


    • 30. Neuroinflammation in Epilepsy: Cellular and Molecular Mechanisms


    • Ray Dingledine, Nicholas Varvel, Teresa Ravizza, and Annamaria Vezzani


    • 31. Role of Reactive Oxygen Species in Epilepsy


    • Ashwini Sri Hari, Matthew C. Walker, and Manisha Patel


    • 32. BDNF/TrkB Signaling and Epileptogenesis


    • Stephen Harward, Yang Huang, and James McNamara


    • 33. Clinical Features and Molecular Mechanisms Underlying Autoantibody-Mediated Seizures


    • Alexander Mathy and Sarosh Irani


    • 34. Transcriptomic Alterations in Epileptogenesis: Transcription Factors in the Spotlight


    • Gary Brennan and Karen van Loo


    • 35. Epigenetics


    • Katja Kobow and Nadia Khan


    • SECTION 4 - BIOMARKERS OF EPILEPTOGENESIS


    • Editor: Annamaria Vezzani; Associate Editors: Helen Scharfman and David Henshall


    • Introduction


    • Annamaria Vezzani and David Henshall


    • 36. EEG Biomarkers of Epileptogenesis


    • Lyna Kamintsky, Dan Z Milikovsky, and Alon Friedman


    • 37. Blood Biomarkers: Noncoding RNAs and Proteins


    • David Henshall and Michele Simonato


    • 38. Behavioural Biomarkers of Epileptogenesis and Epilepsy Severity


    • Idrish Ali, Pablo Casillas-Espinosa, Nigel Jones, and Terence O'Brien


    • 39. Genetic and Imaging Biomarkers of Epileptogenesis


    • Matthias Koepp, Simona Balestrini, Stefanie Dedurwaerdere, and William Theodore


    • 40. Machine-Learning Approach to Discover Novel Biomarkers for Post-Traumatic Epilepsy


    • Robert Ciszek, Eppu Manninen, Olli Gröhn, Jussi Tohka, and Asla Pitkÿnen


    • SECTION 5 - GENES AND NETWORK DEVELOPMENT


    • Editors: Antonio Delgado Escueta and Jeffrey Noebels; Associate Editor: Elsa Rossignol


    • Introduction


    • Jeffrey Noebels


    • 41. Human Epilepsy Gene Discovery: The Next Decade


    • Emily Bonkowski and Heather Mefford


    • 42. Functional Exploration of Epilepsy Genes in Patint-Derived Cells


    • Maria 'Carmen' Varela, Ranmal Samarasinghe, and Jack Parent


    • 43. Brain mosaicism in Epileptogenic Cortical Malformations


    • ThÃ(c)o Ribierre and StÃ(c)phanie Baulac


    • 44. Sodium Channelopathies in Human and Animal Models of Epilepsy and Neurodevelopmental Disorders


    • Kazuhiro Yamakawa, Miriam Meisler, and Lori Isom


    • 45. Potassium Channels in Genetic Epilepsy: a Functional Perspective


    • Matthew Weston and Anastasios Tzingounis


    • 46. High Voltage Activated Calcium Channels in Epilepsy: Lessons from Humans and Rodents


    • Elsa Rossignol


    • 47. Transcription Factors Regulating Interneuron Development


    • Emily Ling-Lin Pai, Daniel Vogt, Jia Sheng Hu, and John Rubenstein


    • 48. GABAA Receptors, Seizures and Epilepsy


    • Richard Olsen, Martin Wallner, and Michael A. Rogawski


    • 49. Gene genome interactions - Understanding complex molecular traits in epilepsy


    • Katja Kobow and John Mahoney


    • SECTION - 6 PROGRESSIVE MYOCLONUS EPILEPSIES


    • Editor: Antonio Delgado-Escueta; Associate Editor: Berge Minassian


    • Introduction


    • A.V. Delgado-Escueta, Berge Minassian, Jose M Seratossa


    • 50. The Neuronal Ceroid Lipofuscinoses


    • Sara Mole


    • 51. Progressive Myoclonus Epilepsy: Unverricht-Lundborg Disease


    • Saara Tegelberg, Tarja Joensuu, and Anna-Elina Lehesjoki


    • 52. Strategies on Gene Therapy in Progressive Myoclonus Epilepsies


    • Saima Kayani, Emrah Gumusgoz, Berge Minassian, and Alison Dolce


    • 53. Therapeutic Window for the Treatment of Lafora Disease


    • Olga Varea, Joan Guinovart, and Jordi Duran


    • 54. Progressive Myoclonus Epilepsy of Lafora- Treatment with Metformin


    • Jose M. Seratossa, Daniel F. Burgos, Luis Zafra-Puerta, Nerea Iglesias-Cabeza, Pascual Sanz, and Marina P. Sánchez


    • 55. Treating Lafora Disease with an Antibody-Enzyme Fusion


    • Matthew Gentry, Kia H. Markussen, Ramon Sun, and Craig W. Vander Kooi


    • 56. Antisense Oligonucleotide Therapy for Progressive Myoclonus Epilepsies


    • Silvia Nitschke and Berge Minassian


    • SECTION 7 - COMORBIDITIES OF EPILEPTIC NETWORKS


    • Editor: Jeffrey Noebels; Associate Editor: Peyman Golshani


    • Introduction


    • Jeffrey Noebels


    • 57. Dissecting Epileptic and Cognitive Network Dysfunction in Epilepsy


    • Pierre-Pascal Lenck-Santini and Greg Holmes


    • 58. Attention Deficit Disorders and Epilepsy


    • Atul Maheshwari


    • 59. What Rodent Models Teach Us About the Association of Autism and Epilepsy


    • Peyman Golshani


    • 60. Artificial Intelligence-Guided Behavioral Phenotyping in Epilepsy


    • Tilo Gschwind and Ivan Soltesz


    • 61. Mechanisms of Depression in the Epileptic Brain


    • Nigel Jones and Jamie Maguire


    • 62. Heterogeneous Mechanisms of Spreading Depolarization and Seizures


    • Isamu Aiba


    • 63. Genetic and Cellular Mechanisms Underlying SUDEP Risk


    • Jeffrey Noebels


    • SECTION 8- EPILEPSY THERAPEUTICS


    • Editor: Michael Rogawski; Associate Editors: Wolfgang Löscher and Steve White


    • Introduction


    • Michael Rogawski


    • 64. New Models for Assessment of Antiseizure Activity


    • Cameron Metcalf, Peter West, Sharon Edwards, and Karen Wilcox


    • 65. Disease Biology Factors Accounting for Epilepsy Severity: An Updated Conceptual Framework for New Drug Discovery


    • Stefanie Dedeurwaerdere, Vincenzo Marra, and Michael R Johnson


    • 66. Animal Models of Pharmacoresistant Epilepsy


    • Michelle Guignet and H. Steve White


    • 67. Drug Combinations for Antiepileptogenesis


    • Wolfgang Löscher


    • 68. Prophylaxis of Epileptogenesis in Injury and Genetic Epilepsy Models


    • David Prince and Feng Gu


    • 69. Management of Febrile Status Epilepticus: Past, Present and Future


    • Megan M. Garcia-Curran and Tallie Z. Baram


    • 70. Excitatory Transmission in Status Epilepticus


    • Suchitra Joshi and Jaideep Kapur


    • 71. Ionic Mechanisms of Ictogenic Disinhibition: All GABA Signaling is Local


    • Kevin Staley


    • 72. Epileptogenic Channelopathies Guide Design of NBI-921352, a Highly Isoform-Selective Inhibitor of NaV1.6


    • J.P. Johnson, Jr, Alison J Cutts, James R. Empfield, and Charles J. Cohen


    • 73. Purinergic Signaling in Epilepsy


    • Tobias Engel and Nicholas Dale


    • 74. Anti-Inflammatory Strategies for Disease Modification: Focus on Therapies Close to Clinical Translation


    • Annamaria Vezzani, Silvia Balosso, Nicholas H. Varvel, and Ray Dingledine


    • 75. Targeted Augmentation of Nuclear Gene Output (TANGO)


    • Lori Isom and Kelly G. Knupp


    • 76. Gene Therapy for Epilepsy


    • Kimberly Goodspeed, Dallas Armstrong, Andrea Boitnott, Alison Dolce, Qinglan Ling, and Steve Gray


    • 77. Gene Therapy for Refractory Epilepsy


    • Dimitri Kullmann


    • 78. Cell Therapy for Treatment of Epilepsy


    • Sonja Bröer and Daniel Vogt


    • 79. Mechanisms of Ketogenic Diet Action


    • Robin Williams, Detlev Boison, Susan Masino, and Jong Rho